Dr. Aggrey Dhabangi

Dr. Aggrey Dhabangi (MB ChB), M.Med Paediatrics and Child Health ), PhD (Cand.)

 Aggrey Dhabangi is a Lecturer at the Child Health and Development centre (CHDC), School of Medicine, Makerere University, and currently a PhD candidate at University of Amsterdam. At CHDC, he teaches undergraduate medical students; clinical Paediatrics (4^th and 5^th years), community research projects development and implementation (3^rd year) and research methods and community diagnosis (2^nd year) and well as supervision of medical students at community site placements.

Currently, he is the Ugandan trial co-coordinator of a three year study entitled; Malaria chemoprevention with monthly treatment with dihydroartemisinin-piperaquine for the post-discharge management of severe anaemia in children aged less that 5 years in Uganda and Kenya: a 3-year, multi-centre, parallel-group, two-arm randomized placebo controlled superiority trial.

He has also participated in various research projects at CHDC both qualitative and Quantitative including a survey of gender attitudes among young people in Uganda, a formative research for the Introduction of  Typhoid vaccination and “WASH” interventions in Kasese district -Uganda, client satisfaction with Health services in Uganda, an assessment of the feasibility of two alternative strategies for delivering a full course of the Human Papilloma Virus (HPV) vaccine to girls in and out of schools in Uganda, among others.

His other prior research experiences include; was a local lead principal investigator of two year clinical trial - an R21 NIH-funded project entitled “Transfusion in Malaria” (HL 109518 01A1); based at the Acute care unit, Mulago hospital, Uganda. (NCT01586923), worked as a study physician for the Cytoadherence in Paediatric Malaria project; a 2 year observational Case – control malaria study performed at the Mulago Hospital Acute Care Unit  and a 2 years experience in research, treatment and care for HIV/AIDS infected children including antiretroviral therapy at the Paediatric Infectious Diseases Institute (PIDC), Mulago.

His research interests include, but not limited to; Blood transfusion therapy, Childhood severe anemia, malaria, Early Childhood Development (ECD) and paediatrics HIV/AIDS.

B) PEER-REVIEWED PUBLICATIONS:

Dzik WS, Kyeyune D, Otekat G, Natukunda B, Hume H, Kasirye PG, Ddungu H, Kajja I, Dhabangi A, Mugyenyi GR, Seguin C, Barnes L, Delaney M. Transfusion Medicine in Sub-Saharan Africa: Conference Summary. Transfus Med Rev. 2015 Jul;29 (3):195-204.

Dhabangi A, Ainomugisha B, Cserti-Gazdewich C, Stowell C, Dzik WS. Transfusion medicine illustrated: Cerebral oxygenation during transfusion for profound anemia. Transfusion. 2014 Nov; 54(11):2802.

Erdman LK, Petes C, Lu Z, Dhabangi A, Musoke C, Cserti-Gazdewich CM, Lee CG, Liles WC, Elias JA, Kain KC. Chitinase 3-like 1 is induced by Plasmodium falciparum malaria and predicts outcome of cerebral malaria and severe malarial anaemia in a case-control study of African children. Malar J. 2014 Jul 21; 13(1):279.

Kim H, Erdman LK, Lu Z, Serghides L, Zhong K, Dhabangi A, Musoke C, Gerard C, Cserti-Gazdewich C, Liles WC, Kain KC. Functional roles for C5a and C5aR but not C5L2 in the pathogenesis of human and experimental cerebral malaria. Infect Immun. 2014 Jan; 82(1):371-9.

Dhabangi A, Mworozi E, Lubega IR, Cserti-Gazdewich CM, Maganda A, Dzik WH. The effect of blood storage age on treatment of lactic acidosis by transfusion in children with severe malarial anaemia: a pilot, randomized, controlled trial. Malar J. 2013 Feb 6; 12:55.

Higgins SJ, Xing K, Kim H, Kain DC, Wang F, Dhabangi A, Musoke C, Cserti-Gazdewich CM, Tracey KJ, Kain KC, Liles WC. Systemic release of high mobility group box 1 (HMGB1) protein is associated with severe and fatal Plasmodium falciparum malaria. Malar J. 2013 Mar 19;12:105.

Cserti-Gazdewich CM, Dhabangi A, Musoke C, Ssewanyana I, Ddungu H, Nakiboneka-Ssenabulya D, Nabukeera-Barungi N, Mpimbaza A, Dzik WH. Inter-relationships of cardinal features and outcomes of symptomatic pediatric Plasmodium falciparum malaria in 1,933 children in Kampala, Uganda. Am J Trop Med Hyg. 2013 Apr; 88(4):747-56.

Cserti-Gazdewich CM, Dhabangi A, Musoke C, Ssewanyana I, Ddungu H, Nakiboneka-Ssenabulya D, Nabukeera-Barungi N, Mpimbaza A, Dzik WH. Cytoadherence in paediatric malaria: ABO blood group, CD36, and ICAM1 expression and severe Plasmodium falciparum infection. Br J Haematol.2012 Oct; 159(2):223-36.

Siu GE, Bakeera-Kitaka S, Kennedy CE, Dhabangi A, Kambugu A. HIV serostatus disclosure and lived experiences of adolescents at the Transition Clinic of the Infectious Diseases Clinic in Kampala, Uganda: a qualitative study. AIDS Care. 2012; 24(5):606-11.

S. Bakeera-Kitaka, A. Conesa-Botella, Dhabangi, A. Maganda, A. Kekitiinwa,R. Colebunders, D. R. Boulware. Tuberculosis in human immunodeficiency virus infected Ugandan children starting on antiretroviral therapy, int j tuberc lung dis 2011; 15(8):1082–1086.

Finney CA, Hawkes CA, Kain DC, Dhabangi A, Musoke C, Cserti-Gazdewich C, Oravecz T, Liles WC, Kain KC. S1P is associated with protection in human and experimental cerebral malaria. Mol Med. 2011; 17(7-8):717-25

Erdman LK, Dhabangi A, Musoke C, Conroy AL, Hawkes M, Higgins S, Rajwans N, Wolofsky KT, Streiner DL, Liles WC, Cserti-Gazdewich CM, Kain KC. Combinations of host biomarkers predict mortality among Ugandan children with severe malaria: a retrospective case-control study. PLoS One. 2011 Feb 25;6(2).

Cserti-Gazdewich CM, Dzik WH, Erdman L, Ssewanyana I, Dhabangi A, Musoke C, Kain KC.  Combined measurement of soluble and cellular ICAM-1 among children with Plasmodium falciparum malaria in Uganda. Malar J 2010; 9: 233.

Murphy S, Cserti-Gazdewich C, Dhabangi A, Musoke C, Nabukeera-Barungi N, Price D, King ME, Romero J, Noviski N, Dzik W.  Ultrasound findings in Plasmodium falciparum malaria: a pilot study. Pediatr Crit Care Med. 2011 Mar; 12(2)